Pii: S0968-0896(97)00137-5
نویسنده
چکیده
-Philanthotoxins are noncompetitive inhibitors of the nicotinic acetylcholine receptor and the various glutamate r<.~ceptors. Analogues carrying photoaffinity labels, fluorine atoms for solid-state NMR studies of ligand/receptor interaction, and large head groups such as porphyrins and planar bulky aromatic rings (BIG analogues) for clarifying mode of entry and orientation of analogues in receptors have been synthesized, assayed against the nicotinic acetylcholine receptor, and brief comments are given for the assay results. © 1997 Elsevier Science Ltd.
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Pii: S0968-0896(99)00042-5
ÐUtilization of 17-keto-androstanes as starting materials for the synthesis of aor b-oriented steroidal 20!16-g-carbolactones has been explored following two dierent strategies. A highly ecient, stereospeci®c protocol has been developed for the boriented cis-g-lactone. A dierent approach, involving prior attachment of a 3-carbon side chain on C-17 of a 17-oxo-16b-acetoxyandrostane led to the...
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متن کاملPii: S0968-0896(97)00048-5
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